abstract：Background:Base excision repair (BER) plays an important role in the maintenance of genome integrity and anticancer drug resistance. This study aimed to explore the role of BER gene polymorphisms in response to chemotherapy for advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherap...

journal_title：Chinese medical journal

authors： Dong J,Wang X,Yu Y,Yan X,Cui JW

更新日期：2018-08-20 00:00:00

abstract：Background:Betel quid chewing has been a major risk factor for oral cancer (OC) in southern China. This study aimed to analyze the scientific publications on the relationship between betel quid chewing and OC and construct a model to quantitatively and qualitatively evaluate pertinent publications from 1998 to 2017. M...

journal_title：Chinese medical journal

authors： Wang M,Xiao C,Ni P,Yu JJ,Wang XW,Sun H

更新日期：2018-08-20 00:00:00

abstract：Background:Technical aspects of the correct placement of medial support locking screws in the locking plate for proximal humerus fractures remain incompletely understood. This study was to evaluate the clinical relationship between the number of medial support screws and the maintenance of fracture reduction after lock...

journal_title：Chinese medical journal

authors： Zeng LQ,Zeng LL,Jiang YW,Wei HF,Zhang W,Chen YF

更新日期：2018-08-05 00:00:00

abstract：Background:Ischemia preconditioning (IPC) remains the most powerful intervention of protection against myocardial ischemia/reperfusion injury (IRI), but diabetes can weaken or eliminate its cardioprotective effect and detailed mechanisms remain unclear. In this study, we aimed to explore whether changes of autophagy in...

journal_title：Chinese medical journal

authors： Liu YY,Sun C,Xue FS,Yang GZ,Li HX,Liu Q,Liao X

更新日期：2018-07-20 00:00:00

abstract：Background:Myoclonic epilepsy with ragged red fibers (MERRF) syndrome is characterized by myoclonus, generalized epilepsy, cerebellar ataxia, and ragged red fibers (RRFs) in the muscle. T-to-C transition at nucleotide position 14709 in the mitochondrial tRNA glutamic acid (tRNAGlu) gene has previously been associated w...

journal_title：Chinese medical journal

authors： Ban R,Guo JH,Pu CQ,Shi Q,Liu HX,Zhang YT

更新日期：2018-07-05 00:00:00

abstract：Background:Recent advances in extracorporeal membrane oxygenation (ECMO) have led to increasing interest in its use during cardiopulmonary resuscitation (CPR). However, decisions regarding extracorporeal CPR (ECPR) in children are difficult as a result of limited studies, especially in Asia Pacific. The objective of th...

journal_title：Chinese medical journal

authors： Chen GL,Qiao YR,Ma JH,Wang JX,Hei FL,Yu J

更新日期：2018-06-20 00:00:00

abstract：Background:Development of innovative immunotherapy is imperative to improve the poor survival of the nasopharyngeal carcinoma (NPC) patients. In this study, we evaluated the T cell response to melanoma-associated antigen (MAGE)-A1, MAGE-A3, or synovial sarcoma X-2 (SSX-2) in the peripheral blood of treatment-naive NPC ...

journal_title：Chinese medical journal

authors： Fan PW,Huang L,Chang XM,Feng YN,Yao X,Peng YC,Dong T,Wang RZ

更新日期：2018-06-05 00:00:00

abstract：Background:Increasing evidence has supported the link of intestinal Fusobacterium nucleatum infection to colorectal cancer (CRC). However, the value of F. nucleatum as a biomarker in CRC detection has not been fully defined. In order to reduce the random error and bias of individual research, this meta-analysis aimed t...

journal_title：Chinese medical journal

authors： Peng BJ,Cao CY,Li W,Zhou YJ,Zhang Y,Nie YQ,Cao YW,Li YY

更新日期：2018-06-05 00:00:00

abstract：Background:The role of postradiation systemic therapy in non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) was controversial. Thus, we explored the role of Radiation Therapy Oncology Group recursive partitioning analysis (RTOG-RPA) and graded prognostic assessment (GPA) in identifying population wh...

journal_title：Chinese medical journal

authors： Liu S,Chen P,Liu YW,Gu XN,Qiu XG,Li B

更新日期：2018-05-20 00:00:00

abstract：Objective:Mechanical ventilation (MV) has long been used as a life-sustaining approach for several decades. However, researchers realized that MV not only brings benefits to patients but also cause lung injury if used improperly, which is termed as ventilator-induced lung injury (VILI). This review aimed to discuss the...

journal_title：Chinese medical journal

authors： Chen L,Xia HF,Shang Y,Yao SL

更新日期：2018-05-20 00:00:00

abstract：Background:Facing the increasing prevalence of gestational diabetes mellitus (GDM), this study aimed to evaluate the management of GDM and its association with adverse pregnancy outcomes. Methods:The data of 996 inpatients with GDM who terminated pregnancies in our hospital from January 2011 to December 2015 were coll...

journal_title：Chinese medical journal

authors： Feng R,Liu L,Zhang YY,Yuan ZS,Gao L,Zuo CT

更新日期：2018-05-05 00:00:00

abstract：Background:Patients with major depressive disorder (MDD) usually have high risk of suicidality. Few studies have investigated the effects of stressful life events (SLEs) on the risk of suicide in Chinese patients who have developed MDD. This study aimed to investigate the impact of SLEs on suicidal risk in Chinese pati...

journal_title：Chinese medical journal

authors： Lin JY,Huang Y,Su YA,Yu X,Lyu XZ,Liu Q,Si TM

更新日期：2018-04-20 00:00:00

abstract：Objective:Acute respiratory distress syndrome (ARDS) is an acute and lethal clinical syndrome that is characterized by the injury of alveolar epithelium, which impairs active fluid transport in the lung, and impedes the reabsorption of edema fluid from the alveolar space. This review aimed to discuss the role of pro-re...

journal_title：Chinese medical journal

authors： Wang Q,Yan SF,Hao Y,Jin SW

更新日期：2018-04-20 00:00:00

abstract：Background:Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome. Central nervous system (CNS) involvement is a severe complication, which can lead to rapid disease development and higher morality. However, this has not been given enough attention in adult HLH. Therefore, we carried out this ...

journal_title：Chinese medical journal

authors： Song Y,Pei RJ,Wang YN,Zhang J,Wang Z

更新日期：2018-04-05 00:00:00

abstract：Objective:Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous progress has been made in stem cell biology and regenerative medicine. Human iPSCs have been widely used for disease modeling, drug discovery, and cell therapy development. In this review, we discuss the progress in app...

journal_title：Chinese medical journal

authors： Wang F,Kong J,Cui YY,Liu P,Wen JY

更新日期：2018-04-05 00:00:00

abstract：Background:The outcome of pediatric deceased donor liver transplantation (LT) has not been well studied, especially pediatric deceased donor livers used in adult transplantation. This study aimed to evaluate the efficacy of LT using pediatric deceased donor livers and compare the outcomes between pediatric-to-pediatric...

journal_title：Chinese medical journal

authors： Zhang R,Zhu ZJ,Sun LY,Wei L,Qu W

更新日期：2018-03-20 00:00:00

abstract：Background:Endometriosis is a challenging disease with symptoms such as dysmenorrhea and infertility. However, its etiology is still vague and there is still no effective markers or treatment. This study aimed to profile the circular RNAs (circRNAs) expressed in eutopic endometrium from patients with ovarian endometrio...

journal_title：Chinese medical journal

authors： Xu XX,Jia SZ,Dai Y,Zhang JJ,Li XY,Shi JH,Leng JH,Lang JH

更新日期：2018-03-05 00:00:00

abstract：Background:Pompe disease is a rare lysosomal glycogen storage disorder linked to the acid alpha-glucosidase gene (GAA). A wide clinical and genetic variability exists between patients from different ethnic populations, and the genotype-phenotype correlations are still not well understood. The aim of this study was to r...

journal_title：Chinese medical journal

authors： Liu HX,Pu CQ,Shi Q,Zhang YT,Ban R

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis, but the results from different high TB-endemic countries are different. The aim of this study was to investigate the value of IGRA in the diagnosis of active pulmonary TB (PTB) in China. METHODS:We co...

journal_title：Chinese medical journal

authors： Kang WL,Wang GR,Wu MY,Yang KY,Er-Tai A,Wu SC,Geng SJ,Li ZH,Li MW,Li L,Tang SJ

更新日期：2018-02-05 00:00:00

abstract：BACKGROUND:Nucleolin (NCL) is the most abundant RNA-binding protein in the cell nucleolus and plays an important role in chromatin stability, ribosome assembly, ribosomal RNA maturation, ribosomal DNA transcription, nucleocytoplasmic transport, and regulation of RNA stability and translation efficiency. In addition to ...

journal_title：Chinese medical journal

authors： Lyu QL,Jiang BM,Zhou B,Sun L,Tong ZY,Li YB,Tang YT,Sun H,Liu MD,Xiao XZ

更新日期：2018-02-05 00:00:00

abstract：BACKGROUND:Early neurological deterioration (END) is a prominent issue after recanalization treatment. However, few studies have reported the characteristics of END after endovascular treatment (EVT) as so far. This study investigated the incidence, composition, and outcomes of END after intravenous recombinant tissue ...

journal_title：Chinese medical journal

authors： Zhang YB,Su YY,He YB,Liu YF,Liu G,Fan LL

更新日期：2018-01-20 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase (MMP)-2 plays an important role in the remodeling of left ventricles (LVs) and right ventricles (RVs). We investigated the differences of MMP-2 expression between LV and RV in response to nandrolone decanoate (ND), swimming training (ST), and combined ND and ST (NS) in mice, based on...

journal_title：Chinese medical journal

authors： Bai Y,Shi XB,Zhang YQ,Wang YL,Liu XY,Esteve-Pastor MA

更新日期：2018-01-20 00:00:00

abstract：BACKGROUND:Eating disorders (EDs) are serious illnesses associated with medical complications and have been increased, especially among societies with an excessive concern about weight, shape, or appearance. This study aimed to investigate the prevalence of EDs among the individuals attending weight management centers ...

journal_title：Chinese medical journal

authors： Eladawi N,Helal R,Niazy NA,Abdelsalam S

更新日期：2018-01-05 00:00:00

abstract：BACKGROUND:Antiplatelet therapy (APT) was prevalently being used in the prevention of vascular disease, but the influence of prior APT on the prognosis of patients with intracerebral hemorrhage (ICH) remains controversial. This meta-analysis was to explore the effects of prior APT on the prognosis of patients with prim...

journal_title：Chinese medical journal

authors： Yu HH,Pan C,Tang YX,Liu N,Zhang P,Hu Y,Zhang Y,Wu Q,Deng H,Li GG,Li YY,Nie H,Tang ZP

更新日期：2017-12-20 00:00:00

abstract：BACKGROUND:Restrictive cardiomyopathy (RCM) is the least common cardiomyopathy in which the walls are rigid and the heart is restricted from stretching and filling properly. Cardiac troponin I (cTnI) mutation-caused myofibril Ca2+ hypersensitivity has been shown to be associated with impaired diastolic function. This s...

journal_title：Chinese medical journal

authors： Ding WH,Han L,Xiao YY,Mo Y,Yang J,Wang XF,Jin M

更新日期：2017-12-05 00:00:00

abstract：BACKGROUND:Leber congenital amaurosis (LCA) is a visual disease which is caused by RPE65 mutations and results in retinal degeneration and severe vision loss in early infancy. According to previous researches, mutations of the RPE65 gene account for 16% of all cases of LCA. This study aimed to identify RPE65 gene mutat...

journal_title：Chinese medical journal

authors： Liu J,Bu J

更新日期：2017-11-20 00:00:00

abstract：BACKGROUND:Current treatments for scoliosis have some defects and complications. To study spinal deformities and test novel scoliosis treatments, many animal models of scoliosis have been developed. These models applied a single load to the spine and could not precisely modulate the spinal growth in different dimension...

journal_title：Chinese medical journal

authors： Zhang HY,Li QY,Wu ZH,Zhao Y,Qiu GX

更新日期：2017-11-05 00:00:00

abstract：BACKGROUND:Total knee arthroplasty (TKA) may be associated with serious complications that adversely affect outcomes and increase the likelihood of disability. However, few studies with sufficient sample size have reported postoperative complications following TKA among Chinese patients. This study aimed to evaluate co...

journal_title：Chinese medical journal

authors： Feng B,Lin J,Jin J,Qian WW,Wang W,Weng XS

更新日期：2017-11-05 00:00:00

abstract：BACKGROUND:Sacroiliac (SI) screw fixation is a demanding technique, with a high rate of screw malposition due to the complex pelvic anatomy. TiRobot™ is an orthopedic surgery robot which can be used for SI screw fixation. This study aimed to evaluate the accuracy of robot-assisted placement of SI screws compared with a...

journal_title：Chinese medical journal

authors： Wang JQ,Wang Y,Feng Y,Han W,Su YG,Liu WY,Zhang WJ,Wu XB,Wang MY,Fan YB

更新日期：2017-11-05 00:00:00

abstract：OBJECTIVE:Parkinson's disease (PD) is featured with motor disorder and nonmotor manifestations including psychological symptoms, autonomic nervous system dysfunction, and paresthesia, which results in great inconvenience to the patients' life. The apolipoprotein (Apo) superfamily, as a group of potentially modifiable b...

journal_title：Chinese medical journal

authors： Li L,Liu MS,Li GQ,Tang J,Liao Y,Zheng Y,Guo TL,Kang X,Yuan MT

更新日期：2017-11-05 00:00:00

abstract：BACKGROUND:Cochlear implants (CIs) can improve speech recognition for children with severe congenital hearing loss, and open-set word recognition is an important efficacy measure. This study examined Mandarin open-set word recognition development among Chinese children with CIs and normal hearing (NH). METHODS:This st...

journal_title：Chinese medical journal

authors： Kong Y,Liu X,Liu S,Li YX

更新日期：2017-10-20 00:00:00

abstract：BACKGROUND:Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are X-linked recessive neuromuscular diseases resulting from dystrophin (DMD) gene mutations. It has been known that the carrier of DMD mutations may also have symptoms of the disease. While de novo mutation is quite common in BMD/DMD pati...

journal_title：Chinese medical journal

authors： Yu H,Chen YC,Liu GL,Wu ZY

更新日期：2017-10-05 00:00:00

abstract：BACKGROUND:Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare but potentially life-threatening congenital heart defect. A retrospective analysis was carried out to elucidate the surgical outcomes of ALCAPA in infants and children using follow-up echocardiography. METHODS:From Sep...

journal_title：Chinese medical journal

authors： Gao Y,Zhang J,Huang GY,Liang XC,Jia B,Ma XJ

更新日期：2017-10-05 00:00:00

abstract：Background::Core fucosylation (CF), catalyzed by α-1,6 fucosyltransferase (Fut8) in mammals, plays an important role in pathological processes through posttranslational modification of key signaling receptor proteins, including transforming growth factor (TGF)-β receptors and platelet-derived growth factor (PDGF) recep...

journal_title：Chinese medical journal

authors： Li LK,Wang N,Wang WD,Du XN,Wen XY,Wang LY,Deng YY,Wang DP,Lin HL

更新日期：2017-09-20 00:00:00

abstract：Background::Localized macular edema and retinal nerve fiber layer (RNFL) thinning have been reported shortly after laser in situ keratomileusis (LASIK) in adults. However, it is still unclear how LASIK affects the retina of children. This study aimed to investigate the macular retina and RNFL thickness in children with...

journal_title：Chinese medical journal

authors： Zhao PF,Zhou YH,Zhang J,Wei WB

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:It remains controversial whether patients with Stage II colorectal cancer would benefit from adjuvant chemotherapy after radical resection. The aim of this study was to establish two mathematical models to identify the suitable patients for adjuvant chemotherapy. METHODS:The current study comprised of two s...

journal_title：Chinese medical journal

authors： Wei B,Zheng XM,Lei PR,Huang Y,Zheng ZH,Chen TF,Huang JL,Fang JF,Liang CH,Wei HB

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:The CHA2DS2-VASc score is used clinically for stroke risk stratification in patients with atrial fibrillation (AF). We sought to investigate whether the CHA2DS2-VASc score predicts stroke and death in Chinese patients with sick sinus syndrome (SSS) after pacemaker implantation and to evaluate whether the pre...

journal_title：Chinese medical journal

authors： Mo BF,Lu QF,Lu SB,Xie YQ,Feng XF,Li YG

更新日期：2017-08-20 00:00:00

abstract：OBJECTIVE:Hypertension is an important risk factor of cardiovascular disease and increases mortality in the elderly. However, the available medical evidences are both inconsistent and insufficient regarding establishing credible and useful blood pressure (BP) targets in the hypertensive elderly. This review summarizes ...

journal_title：Chinese medical journal

authors： Liu P,Zheng JG

更新日期：2017-08-20 00:00:00

abstract：BACKGROUND:Some esophageal cancer patients complicated with depression exhibit cognitive impairments. Frontal electroencephalogram (EEG) may be used as a reliable biomarker for prefrontal-mediated cognitive functions. This study was to investigate alterations of EEG and frontal cognitive impairment in esophageal cancer...

journal_title：Chinese medical journal

authors： Cao Y,Chen X,Xie H,Zou L,Hu LJ,Zhou XJ

更新日期：2017-08-05 00:00:00

abstract：OBJECTIVE:The aim of this study was to summarize recent studies on nondopaminergic options for the treatment of motor symptoms in Parkinson's disease (PD). DATA SOURCES:Papers in English published in PubMed, Cochrane, and Ovid Nursing databases between January 1988 and November 2016 were searched using the following k...

journal_title：Chinese medical journal

authors： Du JJ,Chen SD

更新日期：2017-08-05 00:00:00